| Cat. No. |
Product Name |
Information |
| PC-20475 |
TrkA inhibitor V1
TrkA inhibitor
|
TrkA inhibitor V1 is an isoform-selective inhibitor of TrkA kinase with IC50 of 199 nM, 470-fold selectivity over TrkB. |
| PC-20031 |
Emzeltrectinib
TrkB inhibitor
|
Emzeltrectinib is a potent, selective neurotrophic factor tyrosine kinase receptor TrkB inhibitor, shows potential for treatment of Trk kinase-mediated tumor. |
| PC-20024 |
Boditrectinib
pan-TRK inhibitor
|
Boditrectinib (AUM-601, NOV1601, HL5101, CHC-2014) is a highly selective, orally administered, which inhibits not only pan-TRK (TRKA, TRKB, and TRKC), but also resistance mutations of TRKs. |
| PC-49205 |
GNF-5837
pan-TRK inhibitor
|
GNF-5837 (GNF5837) is a potent, selective, and orally bioavailable pan-TRK inhibitor with IC50 values of 11/9/7 nM against TRKA/B/C, respectively. |
| PC-49116 |
Anizatrectinib
TrkA inhibitor
|
Anizatrectinib is a potent and orally active inhibitor of TrkA kinase with potential for inflammatory disease such as prostatitis. |
| PC-73452 |
Utatrectinib
pan-Trk inhibitor
|
Utatrectinib (AZD7451, AZ12607092) is a potent, selective, small molecule pan-Trk (NTRK) inhibitor with IC50 of 0.2-3.0 nM against TrkA, TrkB, and TrkC. |
| PC-73435 |
Paltimatrectinib
Trk inhibitor
|
Paltimatrectinib (PBI-200, PPI-5278) is a small molecule Trk tyrosine kinase inhibitor with antineoplastic activity. |
| PC-73395 |
HJ-01
PTPσ-Trk inhibitor
|
HJ-01 is a small molecule that disrupts PTPσ-Trk interaction, enhances Trk signaling, and promotes sympathetic nerve regeneration over chondroitin sulfate proteoglycans (CSPGs). |
| PC-72113 |
ONO-7579
Trk inhibitor
|
ONO-7579 (ONO7579) is a novel potent, selective, orally available pan-TRK inhibitor. |
| PC-35954 |
GZ389988
TrkA inhibitor
|
GZ389988 (GZ-389988) is a novel potent, selective, locally delivered TrkA inhibitor for the treatment osteoarthritis. |
| PC-35729 |
NSC49652
p75NTR agonist
|
NSC49652 (NSC 49652) is a functional p75NTR agonist targeting the transmembrane domain (TMD) of death receptor p75NTR with IC50 of 10 uM in AraTM assays, alters the relative conformation of p75NTR TMDs and induces dynamic changes in the full-length receptor in mammalian cells. |
| PC-35679 |
CH7057288
pan-TRK inhibitor
|
CH7057288 (CH-7057288) is a novel potent and selective pan-TRK inhibitor with IC50 of 1.1/7.8/5.1 nM for TRKA/TRKB/TRKC, respectively. |
