| Cat. No. |
Product Name |
Information |
| PC-25749 |
B355252
NGF receptor agonist, UCP2 agonist
|
B355252 (B-355252) is a small molecule NGF receptor agonist, potentiates NGF-induced neurite outgrowth, also is a uncoupling protein 2 (UCP2) agonist to regulates mitochondrial dynamics and enhances mitochondrial structural integrity. |
| PC-23115 |
ACD855
pan-Trk PAM
|
ACD855 (Ponazuril) is a potent, pan-Trk positive allosteric modulator (PAM) with EC50 of 1.9, 3.2 and 0.8 uM for TrkA, TrkB and TrkC respectively. |
| PC-20475 |
TrkA inhibitor V1
TrkA inhibitor
|
TrkA inhibitor V1 is an isoform-selective inhibitor of TrkA kinase with IC50 of 199 nM, 470-fold selectivity over TrkB. |
| PC-20031 |
Emzeltrectinib
TrkB inhibitor
|
Emzeltrectinib is a potent, selective neurotrophic factor tyrosine kinase receptor TrkB inhibitor, shows potential for treatment of Trk kinase-mediated tumor. |
| PC-20024 |
Boditrectinib
pan-TRK inhibitor
|
Boditrectinib (AUM-601, NOV1601, HL5101, CHC-2014) is a highly selective, orally administered, which inhibits not only pan-TRK (TRKA, TRKB, and TRKC), but also resistance mutations of TRKs. |
| PC-49205 |
GNF-5837
pan-TRK inhibitor
|
GNF-5837 (GNF5837) is a potent, selective, and orally bioavailable pan-TRK inhibitor with IC50 values of 11/9/7 nM against TRKA/B/C, respectively. |
| PC-49116 |
Anizatrectinib
TrkA inhibitor
|
Anizatrectinib is a potent and orally active inhibitor of TrkA kinase with potential for inflammatory disease such as prostatitis. |
| PC-73452 |
Utatrectinib
pan-Trk inhibitor
|
Utatrectinib (AZD7451, AZ12607092) is a potent, selective, small molecule pan-Trk (NTRK) inhibitor with IC50 of 0.2-3.0 nM against TrkA, TrkB, and TrkC. |
| PC-73435 |
Paltimatrectinib
Trk inhibitor
|
Paltimatrectinib (PBI-200, PPI-5278) is a small molecule Trk tyrosine kinase inhibitor with antineoplastic activity. |
| PC-73395 |
HJ-01
PTPσ-Trk inhibitor
|
HJ-01 is a small molecule that disrupts PTPσ-Trk interaction, enhances Trk signaling, and promotes sympathetic nerve regeneration over chondroitin sulfate proteoglycans (CSPGs). |
| PC-72113 |
ONO-7579
Trk inhibitor
|
ONO-7579 (ONO7579) is a novel potent, selective, orally available pan-TRK inhibitor. |
| PC-35954 |
GZ389988
TrkA inhibitor
|
GZ389988 (GZ-389988) is a novel potent, selective, locally delivered TrkA inhibitor for the treatment osteoarthritis. |
