HIOC

Chemical Structure : HIOC

CAS No.: 314054-36-9

加入收藏

货号: PC-24268Not For Human Use, Lab Use Only.

HIOC is a selective TrkB agonist, elicits prominent TrkB activation at 500 nM, which is comparable to BDNF, potently protects retinas from light-induced retinal degeneration (LIRD).

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

HIOC is a selective TrkB agonist, elicits prominent TrkB activation at 500 nM, which is comparable to BDNF, potently protects retinas from light-induced retinal degeneration (LIRD).
HIOC activates TrkB receptor and its downstream Erk1/2 in a time-dependent manner.
HIOC selectively and potently activates TrkB receptor and its downstream effector Akt in neurons.
HIOC can penetrate the BBB and selectively activate TrkB.
HIOC exerts its neuroprotective actions via TrkB receptor, mitigates retinal damage induced by bright light and exerts strong effect in promoting TrkB activation in mouse brain and retinas.

物理化学性质&存储条件

分子量	301.35
分子式	C16H19N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-(5-hydroxy-1H-indol-3-yl) ethyl]-2-oxopiperidine-3-carboxamide

参考文献

1. Shen J, et al. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3540-5.

HIOC

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

HIOC

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.