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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Trk Receptor-B355252
B355252

Chemical Structure : B355252

CAS No.: 1261576-81-1

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B355252 (B-355252)

货号: PC-25749Not For Human Use, Lab Use Only.

B355252 (B-355252) is a small molecule NGF receptor agonist, potentiates NGF-induced neurite outgrowth, also is a uncoupling protein 2 (UCP2) agonist to regulates mitochondrial dynamics and enhances mitochondrial structural integrity.

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10 mg ￥980 In stock
25 mg ￥1780 In stock
50 mg ￥2880 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

B355252 (B-355252) is a small molecule NGF receptor agonist, potentiates NGF-induced neurite outgrowth, also is a uncoupling protein 2 (UCP2) agonist to regulates mitochondrial dynamics and enhances mitochondrial structural integrity.
B355252 suppresses glutamate-evoked oxidative stress in HT-22 neurons by blocking Ca2+ and ROS production, and altering the expression or phosphorylation states of Erk kinases.
B355252 is capable of potentiating nerve growth factor (NGF)-primed neurite outgrowth in neuronal cell models in a low NGF environment.
B355252 could protect ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and the LDH level, and preventing neuronal apoptosis.

物理化学性质&存储条件

分子量 514.06
分子式 C25H24ClN3O3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide

参考文献

1. Gliyazova NS, et al. Cell Mol Neurobiol. 2016 Oct;36(7):1109-22.

2. Gliyazova NS, et al. BMC Neurosci. 2013 Sep 2;14:93.

3. Wang HK, et al. J Inflamm Res. 2021 Jun 1;14:2363-2376.

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