| Cat. No. |
Product Name |
Information |
| PC-23560 |
TAK-756
TAK1 inhibitor
|
TAK-756 is a potent, selective transforming growth factor β-activated kinase 1 (TAK1) inhibitor with pIC50 of 8.6, 464/60-fold selective over IRAK1/4. |
| PC-73239 |
HS-276
TAK1 inhibitor
|
HS-276 is a potent, highly selective and orally bioavailable TAK1 inhibitor with Ki of 2.5 nM. |
| PC-62810 |
TAK1-IN-1
TAK1 inhibitor
|
TAK1-IN-1 is a potent, selective, Type I (ATP-competitive, DFG-in) TAK1 inhibitor with Kd of 59 nM, a thienopyrimidine scaffold that serves as a good starting point for medicinal chemistry.. |
| PC-61199 |
PF-05381941
TAK1/p38α inhibitor
|
PF-05381941 (PF 05381941, PF05381941) is a potent, dual TAK1/p38a inhibitor with IC50 of 156/186 nM respectively, with good kinome selectivity against 50 representative kinases. |
| PC-61198 |
5Z-7-Oxozeaenol
TAK1 inhibitor
|
5Z-7-Oxozeaenol (5ZO, FR148083) is a potent, selective TAK1 inhibitor with IC50 of 8 nM, displays >33-fold and >62-fold selectivity over MEKK1 and MEKK4 respectively. |
| PC-61197 |
Takinib
TAK1 inhibitor
|
Takinib (EDHS-206) is a potent, selective TAK1 inhibitor with IC50 of 9.5 nM, selectively induces apoptosis following TNF-a stimulation. |
| PC-70029 |
Minnelide
TAK1 inhibitor
|
Minnelide is a water-soluble prodrug of triptolide that is highly effective in reducing pancreatic tumor growth and spread, and improving survival, induces and promotes apoptosis. |
| PC-45814 |
Triptolide
TAK1 inhibitor
|
Triptolide (PG490) is the active diterpene in the traditional Chinese medicine Lei Gong Teng, induces Ca(2+) release by a polycystin-2 (PC2)-dependent mechanism. |
