5Z-7-Oxozeaenol | TAK1 inhibitor | Probechem Biochemicals

Chemical Structure : 5Z-7-Oxozeaenol

CAS No.: 253863-19-3

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5Z-7-Oxozeaenol ((5Z)-7-Oxozeaenol, TAK1 inhibitor 5ZO, FR148083, LL-Z1640-2)

货号: PC-61198Not For Human Use, Lab Use Only.

5Z-7-Oxozeaenol (5ZO, FR148083) is a potent, selective TAK1 inhibitor with IC50 of 8 nM, displays >33-fold and >62-fold selectivity over MEKK1 and MEKK4 respectively.

规格	价格	库存
2 mg	￥2980	In stock
5 mg	￥5580	In stock
10 mg	￥8980	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

5Z-7-Oxozeaenol (5ZO, FR148083) is a potent, selective TAK1 inhibitor with IC50 of 8 nM, displays >33-fold and >62-fold selectivity over MEKK1 and MEKK4 respectively.
5Z-7-Oxozeaenol inhibits IL-1-induced activation of NF-κB (IC50= 83 nM) and JNK/p38, inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF-α-induced apoptosis in vitro.
5Z-7-Oxozeaenol significantly enhances chemotherapeutic efficacy in vivo.

物理化学性质&存储条件

分子量	362.37
分子式	C19H22O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione

参考文献

1. Ninomiya-Tsuji J, et al. J Biol Chem. 2003 May 16;278(20):18485-90.

2. Choo MK, et al. Mol Cancer Ther. 2006 Dec;5(12):2970-6.

3. Sogabe Y, et al. Bioorg Med Chem Lett. 2015 Feb 1;25(3):593-6.

4. Fan Y, et al. Apoptosis. 2013 Oct;18(10):1224-34.

5Z-7-Oxozeaenol ((5Z)-7-Oxozeaenol, TAK1 inhibitor 5ZO, FR148083, LL-Z1640-2)

生物&药学活性

物理化学性质&存储条件

参考文献

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5Z-7-Oxozeaenol ((5Z)-7-Oxozeaenol, TAK1 inhibitor 5ZO, FR148083, LL-Z1640-2)

生物&药学活性

物理化学性质&存储条件

参考文献

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