Takinib (EDHS-206) | TAK1 inhibitor | Probechem Biochemicals

Chemical Structure : Takinib

CAS No.: 1111556-37-6

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Takinib (EDHS-206, EDHS206)

货号: PC-61197Not For Human Use, Lab Use Only.

Takinib (EDHS-206) is a potent, selective TAK1 inhibitor with IC50 of 9.5 nM, selectively induces apoptosis following TNF-a stimulation.

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生物&药学活性

Takinib (EDHS-206) is a potent, selective TAK1 inhibitor with IC50 of 9.5 nM, selectively induces apoptosis following TNF-a stimulation.
Takinib weakly inhibits IRAK4, IRAK1, GCK, CLK2, and MINK1 with IC50 of 120-430 nM against the MRC Dundee kinase panel.
Takinib does not inhibit any of the MAP2Ks or MAP3Ks family members.
Takinib inhibits phosphorylation of IKK, MAPK 8/9, and c-Jun, induces apoptosis in RA fibroblast-like synoviocytes and reduces IL-6 secretion, induces TNF-α-dependent cell death in rheumatoid arthritis and breast cancer cells.

物理化学性质&存储条件

分子量	322.368
分子式	C18H18N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,3-Benzenedicarboxamide, N1-(1-propyl-1H-benzimidazol-2-yl)-

参考文献

1. Totzke J, et al. Cell Chem Biol. 2017 Aug 17;24(8):1029-1039.e7.

Takinib (EDHS-206, EDHS206)

生物&药学活性

物理化学性质&存储条件

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Takinib (EDHS-206, EDHS206)

生物&药学活性

物理化学性质&存储条件

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