| Cat. No. |
Product Name |
Information |
| PC-62549 |
p32 inhibitor M36
p32 inhibitor
|
p32 inhibitor M36 is a novel small molecule inhibitor of p32 mitochondrial protein, binds directly to p32 and inhibits p32 association with LyP-1. |
| PC-62477 |
UCN-01
PKC inhibitor
|
UCN-01 (7-Hydroxystaurosporine, NSC 638850) is a synthetic derivative of staurosporine that has antiproliferative activity against several in vitro and in vivo cancer models. |
| PC-62415 |
PS432
PKC inhibitor
|
PS432 is an allosteric inhibitor of PKCι and PKCζ with IC50 of 16.9 and 18.5 uM, respectively. |
| PC-62375 |
BJE6-106
PKCδ inhibitor
|
BJE6-106 (B106) is a potent, selective PKCδ inhibitor with IC50 of 50 nM, displays excellent selectivity over classical PKC isozymes (a 1,000-fold PKCδ selectivity over PKCα). |
| PC-62078 |
LY379196
PKCβ inhibitor
|
LY379196 is a highly specific PKCβ inhibitor with IC50 of 30-50 nM for PKCβI and PKCβII, displays >10-fold selectivity of PKCα, δ, η, and γ (>600 nM). |
| PC-62077 |
CGP-53353
PKCβII inhibitor
|
CGP-53353 (DAPH-7) is a selective inhibitor of PKCβII with IC50 of 0.41 uM, shows weak activity on PKCβI with IC50 of 3.8 uM. |
| PC-61793 |
Rottlerin
PKCδ inhibitor
|
Rottlerin (Mallotoxin, NSC 94525) is a polyphenol natural product, cell-permeable and reversible PKC inhibitor that exhibits greater selectivity for PKCδ (IC50=3-6 uM) and PKCθ, with significantly reduced potency (IC50=30-42 uM) for PKCα, PKCβ, and PKCγ. |
| PC-61296 |
OSU-2S
PKCδ activator
|
OSU-2S is a non-immunosuppressive FTY720 analogue, PKCδ activator with higher antiproliferative potency with IC50 of 2.4, 2.4, and 3.5 uM in Huh7, Hep3B, and PLC5 cells, respectively. |
| PC-70263 |
Calphostin C
PKC inhibitor
|
Calphostin C (UCN 1028C, PKF115-584) is a potent, selective and photo-dependent inhibitor of PKC with IC50 of 50 nM. |
| PC-60994 |
AS2521780
PKCθ inhibitor
|
AS2521780 is a potent, selective, orally bioavailable PKCθ inhibitor that inhibits combinant human PKCθ enzyme with IC50 of 0.48 nM, >30-fold higher than other PKC isoforms. |
| PC-60684 |
Go6976
PKC inhibitor
|
Go6976 is a potent, selective protein kinase C (PKC) inhibitor that selectively inhibits PKCα and PKCβ1 with IC50 of 2.3 and 6.2 nM, respectively. |
| PC-60366 |
PKC-IN-6c
PKC inhibitor
|
PKC inhibitor 6c (PKC-IN-6c) is a potent, brain permeant PKC inhibitor with IC50 of 80 nM, without detectable binding to the estrogen receptor (Ki>10 uM). |
