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首页-小分子抑制剂&激动剂-TGF-beta/Smad-PKC-LY379196
LY379196

Chemical Structure : LY379196

CAS No.: 737736-10-6

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LY379196 (LY-379196)

货号: PC-62078Not For Human Use, Lab Use Only.

LY379196 is a highly specific PKCβ inhibitor with IC50 of 30-50 nM for PKCβI and PKCβII, displays >10-fold selectivity of PKCα, δ, η, and γ (>600 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    LY379196 is a highly specific PKCβ inhibitor with IC50 of 30-50 nM for PKCβI and PKCβII, displays >10-fold selectivity of PKCα, δ, η, and γ (>600 nM).
    LY379196 blocks TPA-induced monocytic differentiation of HL60 cells.

    物理化学性质&存储条件

    分子量
    分子式 C29H30N4O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (12E,32E,6S)-6-((dimethylamino)methyl)-22,25-dihydro-11H,21H,31H-1,3(3,1)-diindola-2(3,4)-pyrrolacyclononaphane-22,25-dione

    参考文献

    1. Jirousek MR, et al. J Med Chem. 1996 Jul 5;39(14):2664-71.

    2. Slosberg ED, et al. Mol Carcinog. 2000 Mar;27(3):166-76.

    3. Tabit CE, et al. Circulation. 2013 Jan 1;127(1):86-95.

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