Chelerythrine chloride

Chemical Structure : Chelerythrine chloride

CAS No.: 3895-92-9

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货号: PC-42863Not For Human Use, Lab Use Only.

Chelerythrine chloride is a potent, cell-permeable inhibitor of PKC (IC50=66 nM) and p38 MAPK, also inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 uM and displaces Bax from Bcl-XL.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg	￥3980	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Chelerythrine chloride is a potent, cell-permeable inhibitor of PKC (IC50=66 nM) and p38 MAPK, also inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 uM and displaces Bax from Bcl-XL.
Chelerythrine chloride inhibits LPS-induced TNF-α level and NO production in LPS-induced murine peritoneal macrophages through selective inhibition of p38 MAPK and ERK1/2 activation.
Chelerythrine chloride triggers apoptosis via direct action on mitochondria.

物理化学性质&存储条件

分子量	383.8249
分子式	C21H18ClNO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 3.9 mg/mL
Chemical Name/SMILES	1,2-Dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium chloride

参考文献

1. Chan SL, et al. J Biol Chem. 2003 Jun 6;278(23):20453-6.

2. Li W, et al. Inflammation. 2012 Dec;35(6):1814-24.

3. Wan KF, et al. J Biol Chem. 2008 Mar 28;283(13):8423-33.

4. Zhang YH, et al. J Mol Biol. 2006 Dec 1;364(3):536-49.