PS432|CAS:2083630-26-4 Probechem Biochemicals

Chemical Structure : PS432

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PS432 (PS-432)

货号: PC-62415Not For Human Use, Lab Use Only.

PS432 is an allosteric inhibitor of PKCι and PKCζ with IC50 of 16.9 and 18.5 uM, respectively.

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生物&药学活性

PS432 is an allosteric inhibitor of PKCι and PKCζ with IC50 of 16.9 and 18.5 uM, respectively.
PS432 has no inhibitory activity against PKCα, PKCβ, PKCδ and PKCθ nor the activity of related kinases such as PDK1, PKB/Akt, RSK1, MSK1 and Aurora A.
PS432 inhibits the proliferation of the lung cancer cell lines A549 (IC50=14.8 ± 4.2 uM) and A427 (IC50=10.4± 0.3 uM) as well as androgen-independent prostate cancer cell line DU145 (IC50 = 20.8 ± 9.0 uM); well tolerated in vivo.

物理化学性质&存储条件

分子量	494.946
分子式	C25H19ClN2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 2-(5-(4-chlorophenyl)furan-2-yl)-4-hydroxy-1-(6-methylbenzo[d]thiazol-2-yl)-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate

参考文献

1. Arencibia JM, et al. ACS Chem Biol. 2017 Feb 17;12(2):564-573.

PS432 (PS-432)

生物&药学活性

物理化学性质&存储条件

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PS432 (PS-432)

生物&药学活性

物理化学性质&存储条件

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