Calphostin C | PKC inhibitor Probechem

Chemical Structure : Calphostin C

CAS No.: 121263-19-2

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Calphostin C (UCN 1028C, PKF115-584)

货号: PC-70263Not For Human Use, Lab Use Only.

Calphostin C (UCN 1028C, PKF115-584) is a potent, selective and photo-dependent inhibitor of PKC with IC50 of 50 nM.

规格	价格	库存
100 ug	￥4580	In stock
500 ug	￥9580	In stock
1 mg		Get quote
5 mg		Get quote

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生物&药学活性

Calphostin C (UCN 1028C, PKF115-584) is a potent, selective and photo-dependent inhibitor of PKC with IC50 of 50 nM.
Calphostin C displays >1,000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase.
Calphostin C inhibits cell growth and promotes apoptosis in HeLa S3 and MCF-7 cells with IC50 of 0.23 and 0.18 uM, respectively.
Calphostin C also inhibits phospholipase D1 and D2 (IC50=100 nM).
Calphostin C also blocks β-catenin/Tcf transcriptional activity.

物理化学性质&存储条件

分子量	790.76
分子式	C44H38O14
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4,9-dihydroxy-12-(2-(((4-hydroxyphenoxy)carbonyl)oxy)propyl)-2,6,7,11-tetramethoxy-3,10-dioxo-3,10-dihydroperylen-1-yl)propan-2-yl benzoate

参考文献

1. Sukhdeo K, et al. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7516-21.

2. Kobayashi E, et al. J Antibiot (Tokyo). 1989 Oct;42(10):1470-4.

3. Sciorra VA, et al. Biochemistry. 2001 Feb 27;40(8):2640-6.

Calphostin C (UCN 1028C, PKF115-584)

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Calphostin C (UCN 1028C, PKF115-584)

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