| Cat. No. |
Product Name |
Information |
| PC-28486 |
DSB1559
PARP1 inhibitor
|
DSB1559 is a potent, selective and blood-brain barrier permeable PARP1 inhibitor with IC50 of 2 nM, >2000-fold selectivity compared with PARP2. |
| PC-28106 |
PP-048
Polθ/PARP1 inhibitor
|
PP-048 is a potent, selective, second-generation dual inhibitor of Polθ and PARP1 with IC50 of 4.9 nM and 6.8 nM, respectively, shows >226-fold selectivity over PARP2, PARP3, PARP5a/b, and PARP7. |
| PC-28011 |
YHD-26
GPX4/PARP inhibitor
|
YHD-26 is a novel ferroptosis inducer and dul GPX4/PARP inhibitor, inhibits PARP (IC50=92 nM) and binds GPX4 (KD=23.4 uM). |
| PC-27717 |
TSL-1502M
PARP inhibitor
|
TSL-1502M is a potent PARP1 and PARP2 inhibitor with IC50 of 0.66 nM and 0.87 nM respectively. |
| PC-27716 |
TSL-1502
PARP inhibitor
|
TSL-1502 is a glucuronide prodrug of poly (ADP-ribose) polymerase (PARP) inhibitor TSL-1502M, which is a potent PARP1 and PARP2 inhibitor with IC50 of 0.66 nM and 0.87 nM respectively. |
| PC-26761 |
FORX-428
PARG inhibitor
|
FORX-428 (FORX428) is a highly potent, selective and orally bioavailable PARG inhibitor with IC50 of 0.29 nM and 0.25 nM for PARG WT human and PARG WT mouse respectively. |
| PC-26517 |
DB008
PARP16 inhibitor
|
DB008 is a selective, covalent PARP16 inhibitor with IC50 of 0.275 uM, covalently reacts with a non-conserved cysteine (Cys169, human numbering) in the NAD+ binding pocket of PARP16. |
| PC-25071 |
Lotixparib
PARP1 inhibitor
|
Lotixparib (DM5167) is a potent, selective PARP1 inhibitor with IC50 of 0.41 nM, displays >300-fold preference for PARP1 over PARP2 in in vitro enzymatic and DNA capture assays. |
| PC-24241 |
TDI-012804
TNKS2 inhibitor
|
TDI-012804 is a potent and selective Tankyrase 2 (TNKS2) inhibitor with IC50 of 3.46 nM in in vitro PARylation assays, has 25-fold selectivity over TNKS1, suppresses WNT signaling in TNKS depleted cells. |
| PC-24140 |
Itareparib
PARP1 inhibitor
|
Itareparib (NMS-293, NMS-03305293) is a potent, selective PARP-1 inhibitor with IC50 of <0.01 uM, shows potential for treatment of cancer, cardiovascular disease, central nervous system injury, and inflammation. |
| PC-23876 |
Talazoparib
PARP1/2 inhibitor
|
Talazoparib (BMN-673) is a highly potent, selective PARP1/2 inhibitor (PARP1, IC50=0.57 nM), inhibits PARP1 and PARP2 to a similar extent with Ki of 1.20 and 0.85 nM, respectively. |
| PC-23684 |
DM5167 hydrochloride
PARP1 inhibitor
|
Lotixparib hydrochloride (DM5167 hydrochloride) is a potent, selective PARP1 inhibitor with IC50 of 0.41 nM, displays >300-fold preference for PARP1 over PARP2 in in vitro enzymatic and DNA capture assays. |
