RBN3143 | PARP14 inhibitor | Probechem Biochemicals

Chemical Structure : RBN3143

CAS No.: 2360853-16-1

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RBN3143 (RBN-3143, RBN 3143)

货号: PC-20898Not For Human Use, Lab Use Only.

RBN3143 (RBN-3143) is a potent, selective, NAD+-competitive catalytic inhibitor of PARP14 with IC50 of 4 nM, >300-fold selectivity over other ADP-ribosyltransferase (ART) family members.

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5 mg	￥2180	In stock
10 mg	￥3580	In stock
25 mg	￥5480	In stock
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100 mg		Get quote

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生物&药学活性

RBN3143 (RBN-3143) is a potent, selective, NAD+-competitive catalytic inhibitor of PARP14 with IC50 of 4 nM, >300-fold selectivity over other ADP-ribosyltransferase (ART) family members.
RBN-3143 broadly suppressed disease phenotypes such as airway mucus, serum-IgE levels, and the accumulation of immune cells and inflammatory cytokines in the BALF in a mouse model of severe, steroid-resistant asthma.
RBN-3143 also suppressed the accumulation of alarmins TSLP, IL-33, and IL-25.
RBN-3143 is the first small molecule inhibitor of PARP14 entering clinical trials.

物理化学性质&存储条件

分子量	449.54
分子式	C22H28FN3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-((1-acetylpiperidin-4-yl)methoxy)-5-fluoro-2-(((tetrahydro-2H-pyran-4-yl)thio)methyl)quinazolin-4(3H)-one

参考文献

1. Niepel M, et, al. European Respiratory Journal 2022 60: 4642.

RBN3143 (RBN-3143, RBN 3143)

生物&药学活性

物理化学性质&存储条件

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RBN3143 (RBN-3143, RBN 3143)

生物&药学活性

物理化学性质&存储条件

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