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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-XAV939
XAV939

Chemical Structure : XAV939

CAS No.: 284028-89-3

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XAV939 (XAV-939, XAV 939)

货号: PC-21186Not For Human Use, Lab Use Only.

XAV939 is a potent small molecule inhibitor of Tankyrases with IC50 of 5 nM and 2 nM for TNKS1 and TNKS2, respectively, selectively inhibits beta-catenin-mediated transcription.

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50 mg ￥1980 In stock
100 mg ￥2980 In stock
200 mg ￥4580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

XAV939 is a potent small molecule inhibitor of Tankyrases with IC50 of 5 nM and 2 nM for TNKS1 and TNKS2, respectively, selectively inhibits beta-catenin-mediated transcription.
XAV939 stimulates beta-catenin degradation by stabilizing axin.
XAV939 stabilize Axin2 levels in oligodendrocyte progenitor cells (OLPs) from brain and spinal cord and accelerated their differentiation and myelination after hypoxic and demyelinating injury.
XAV939 increases Axin1 and Axin2 protein levels and attenuates Wnt-induced transcriptional responses in several breast cancer lines.
XAV939 attenuates Wnt3a induced cell migration in MDA-MB-231 cells.
XAV939 is an inhibitor of canonical WNT signalling.

物理化学性质&存储条件

分子量 312.31
分子式 C14H11F3N2OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-(Trifluoromethyl)phenyl)-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one

参考文献

1. Huang SM, et al. Nature. 2009 Oct 1;461(7264):614-20.

2. Karlberg T, et al. J Med Chem. 2010 Jul 22;53(14):5352-5.

3. Fancy SP, et al. Nat Neurosci. 2011 Jun 26;14(8):1009-16.

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