| Cat. No. |
Product Name |
Information |
| PC-23373 |
PR-104A
DNA alkylating agent
|
PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin, alcohol metabolite of phosphate proagent PR-104, which shows selective DNA cross-linking selective cytotoxicity under hypoxia in cancer cells. |
| PC-23371 |
PR-104
DNA alkylating agent
|
PR-104 is a hypoxia-activated DNA cross-linking agent and phosphate ester of the nitrogen mustard prodrug PR-104A, shows selective DNA cross-linking selective cytotoxicity under hypoxia in cancer cells. |
| PC-22218 |
SJG-136
DNA cross-linking agent
|
SJG-136 (SG2000, NSC 694501) is a potent DNA cross-linking agent and DNA-binding payload with XL50 (50% cross-linking of pBR322 DNA) of 45 nM, shows potent antitumor activity. |
| PC-22197 |
LP-184
Alkylating agent
|
LP-184 is an acylfulvene alkylating agent, inhibits viability of multiple GBM cell isolates including temozolomide-resistant and MGMT-expressing cells with IC50 of 22-310 nM. |
| PC-21822 |
QN-302
G-quadruplex binder
|
QN-302 (SOP1812) is a tetrasubstituted naphthalene diimide compound binding to G-quadruplex (G4) DNA structures, shows high potency in pancreatic ductal adenocarcinoma (PDAC) cells. |
| PC-20967 |
VAL-083
Alkylating agent
|
VAL-083 (Dianhydrodulcitol) is a small alkylating molecule that induces interstrand DNA crosslinking, induces persistent DNA double-strand breaks (DSB) and cell-cycle arrest in a p53-dependent or p53-independent manner. |
