PR-104 | DNA alkylating agent | Probechem Biochemicals

Chemical Structure : PR-104

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PR-104 (PR104)

货号: PC-23371Not For Human Use, Lab Use Only.

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生物&药学活性

PR-104 is a hypoxia-activated DNA cross-linking agent and phosphate ester of the nitrogen mustard prodrug PR-104A, shows selective DNA cross-linking selective cytotoxicity under hypoxia in cancer cells.
The cytotoxicity of PR-104A was increased 10- to 100-fold by hypoxia in vitro.
PR-104 is reduced to activated DNA cross-linking metabolites (hydroxylamine PR-104H and amine PR-104M) under hypoxia by one-electron reductases and independently of hypoxia by the 2-electron reductase aldo-keto reductase 1C3 (AKR1C3).
Overexpression of AKR1C3 in a resistant BCP-ALL xenograft resulted in dramatic sensitization to PR-104 in vivo.
PR-104 showed significantly greater efficacy against T-lineage ALL (T-ALL) than B-cell-precursor ALL (BCP-ALL) xenografts.

物理化学性质&存储条件

分子量	579.27
分子式	C14H20BrN4O12PS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2-bromoethyl)(2,4-dinitro-6-((2-(phosphonooxy)ethyl)carbamoyl)phenyl)amino)ethyl methanesulfonate

参考文献

1. Moradi Manesh D, et al. Blood. 2015 Sep 3;126(10):1193-202.

2. McKeage MJ, et al. BMC Cancer. 2012 Oct 25;12:496.

3. Adam V Patterson, et al. Clin Cancer Res. 2007 Jul 1;13(13):3922-32.

PR-104 (PR104)

生物&药学活性

物理化学性质&存储条件

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PR-104 (PR104)

生物&药学活性

物理化学性质&存储条件

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