Ecteinascidin 770 |CAS:114899-80-8 Probechem Biochemicals

Chemical Structure : Ecteinascidin 770

CAS No.: 114899-80-8

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Ecteinascidin 770 (Ecteinascidine 770;Et 770;Et-770;Et770)

货号: PC-42331Not For Human Use, Lab Use Only.

A tetrahydroisoquinoline alkaloid with potent anticaner activities.

规格	价格	库存
5 mg	￥2800	In stock
10 mg	￥4000	In stock
50 mg	￥12000	In stock
100 mg	￥16800	In stock

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生物&药学活性

A tetrahydroisoquinoline alkaloid with potent anticaner activities; shows cytotoxicity against human cell lines HCT116, QG56, and DU145 with IC50 of 0.60, 2.4, and 0.81 nM, respectively; sensitizes H23 the cells by activating the p53 protein, down-regulates MCL1 and up-regulates BAX proteins, with no effect on Bcl-2; enhances anoikis response of human lung cancer H23 and H460 cells.

物理化学性质&存储条件

分子量	770.84728
分子式	C40H42N4O10S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-14-carbonitrile, 5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8-dihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-, (1'R,6R,6aR,

参考文献

1. Saktrakulkla P, et al. Bioorg Med Chem. 2011 Aug 1;19(15):4421-36.

2. Powan P, et al. Anticancer Res. 2013 Feb;33(2):505-12.

3. Puthongking P, et al. Chem Pharm Bull (Tokyo). 2006 Jul;54(7):1010-6.

Ecteinascidin 770 (Ecteinascidine 770;Et 770;Et-770;Et770)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

Ecteinascidin 770 (Ecteinascidine 770;Et 770;Et-770;Et770)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

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询单

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