Satraplatin |CAS:129580-63-8 Probechem Biochemicals

Chemical Structure : Satraplatin

CAS No.: 129580-63-8

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Satraplatin (BMS182751, BMY-45594, JM-216)

货号: PC-45364Not For Human Use, Lab Use Only.

Satraplatin (BMS-182751, BMY-45594, JM-216) is a platinum-based antineoplastic agent that binds to guanine residues in DNA, inhibits DNA replication and transcription, leads to subsequent apoptosis.

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生物&药学活性

Satraplatin (BMS-182751, BMY-45594, JM-216) is a platinum-based antineoplastic agent that binds to guanine residues in DNA, inhibits DNA replication and transcription, leads to subsequent apoptosis.
Satraplatin shows similar cytotoxicity and pattern of cytotoxicity to cisplatin against human ovarian carcinoma cell lines (IC50=1.7 uM).
Satraplatin shows antitumor selectivity far superior to cisplatin, carboplatin, or tetraplatin in vivo; orally active.

物理化学性质&存储条件

分子量	500.2816
分子式	C10H22Cl2N2O4Pt+2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	Platinum, bis(acetato-κO)amminedichloro(cyclohexanamine)-, (OC-6-43)- (9CI)

参考文献

1. Kelland LR, et al. Cancer Res. 1993 Jun 1;53(11):2581-6.

2. Mellish KJ, et al. Br J Cancer. 1993 Aug;68(2):240-50.

3. Ricart AD, et al. Clin Cancer Res. 2009 Jun 1;15(11):3866-71.

Satraplatin (BMS182751, BMY-45594, JM-216)

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Satraplatin (BMS182751, BMY-45594, JM-216)

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物理化学性质&存储条件

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