| Cat. No. |
Product Name |
Information |
| PC-42257 |
GMX1778
NAMPT inhibitor
|
GMX1778 (CHS-828) is a potent, specific, competitive NAMPT inhibitor with Kd of 120 nM, enzyme IC50 of <25 nM. |
| PC-45883 |
FK866
NAMPT inhibitor
|
FK866 (Daporinad, APO-866) is a potent, highly specific nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with Ki of 0.4 nM. |
| PC-27316 |
NAMPT activator compound b2b
NAMPT activator
|
NAMPT activator compound b2b is a potent lipid-lowering compound (EC50=0.37 uM) and NAMPT activator, binds to NAMPT with a dissociation constant (KD) of 0.78 uM, inhibits triglyceride biosynthesis by inhibiting ACSL1 in adipocytes. |
| PC-27013 |
GR2-128
MLK3/NAMPT inhibitor
|
GR2-128 is a potent, dual Mixed lineage kinase 3 (MLK3) and NAMPT inhibitor with IC50 of 84 nM and 14 nM respectively, inhibits antiproliferative in MDA-MB-468 TNBC cell line with GI50 of 42 nM. |
| PC-25053 |
β-Nicotinamide mononucleotide
CAS 1094-61-7
|
β-Nicotinamide mononucleotide (NMN) is an iconic anti-aging drug that increases NAD+ levels, activates NAD+/SIRT3 signaling pathway, a precursor of NAD(+) and NAMPT reaction product. |
| PC-22010 |
LZFPN-90
NAMPT/PD-L1 inhibitor
|
LZFPN-90 (LZ90) is a potent, dual NAMPT/PD-L1 targeting inhibitor with IC50 of 13 nM/28 nM for PD-1/PD-L1 and NAMPT, respectively. |
| PC-21428 |
A4276
NAMPT inhibitor
|
A4276 is a novel orally bioavailable NAMPT inhibitor with IC50 of 492 nM for inhibiting NAMPT enzymatic activity, shows high selectivity for NAPRT-deficient lung cancer cell lines. |
| PC-21052 |
MM201
NAMPT inhibitor
|
MM201 is a novel potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with IC50 of 74.3 nM in in vitro biochemical assays. |
