LZFPN-90 | NAMPT/PD-L1 inhibitor | Probechem Biochemicals

Chemical Structure : LZFPN-90

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LZFPN-90 (LZ90, LZFPN90)

货号: PC-22010Not For Human Use, Lab Use Only.

LZFPN-90 (LZ90) is a potent, dual NAMPT/PD-L1 targeting inhibitor with IC50 of 13 nM/28 nM for PD-1/PD-L1 and NAMPT, respectively.

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生物&药学活性

LZFPN-90 (LZ90) is a potent, dual NAMPT/PD-L1 targeting inhibitor with IC50 of 13 nM/28 nM for PD-1/PD-L1 and NAMPT, respectively.
LZFPN-90 treatment (0-20 uM) resulted in a concentration-dependent reduction in the NAD+ content in A2780 cells, also reduced NAD+ content in tumor tissues in vivo.
LZFPN-90 could inhibit cancer cell proliferation, arrest the cell cycle in the G2/M phase, and promote apoptosis by inhibiting NAMPT activity.
LZFPN-90 could promote T-cell proliferation, activate CD8+ toxic T cells, and enhance the secretion of IFN-γ and GzmB, thereby killing tumor cells.
LZFPN-90 (20 mg/kg, 40 mg/kg, i.p.) inhibits tumor growth in double-target overexpressed xenograft models and organoids.
LZFPN-90 exerts antitumor effects dependent on NAMPT and PD-L1 in the LLC OE NAMPT/PD-L1 mouse model.

物理化学性质&存储条件

分子量	608.77
分子式	C33H36N8O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-cyano-1-((2-(4-(3-(3-(diethylamino)propoxy)phenyl)indoline-1-carbonyl)thiazol-5-yl)methyl)-3-(pyridin-4-yl)guanidine

参考文献

1. Yuan Yang, et al. EMBO Mol Med. 2024 Mar 6. doi: 10.1038/s44321-024-00051-z.

LZFPN-90 (LZ90, LZFPN90)

生物&药学活性

物理化学性质&存储条件

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LZFPN-90 (LZ90, LZFPN90)

生物&药学活性

物理化学性质&存储条件

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