LSN 3154567 |CAS:1698878-14-6 Probechem Biochemicals

Chemical Structure : LSN 3154567

CAS No.: 1698878-14-6

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LSN 3154567 (LSN-3154567;LSN3154567)

货号: PC-60773Not For Human Use, Lab Use Only.

LSN3154567 is a novel potent, highly selective, competitive NAMPT inhibitor with IC50 of 3.1 nM.

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10 mg	￥1580	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
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生物&药学活性

LSN3154567 is a novel potent, highly selective, competitive NAMPT inhibitor with IC50 of 3.1 nM.
LSN3154567 exhibit no significant activity against the CEREP Kinase panel except CSF1R (IC50=0.84 uM).
LSN3154567 exhibits a broad spectrum of anti-cancer activity against different types of cancer cell lines, exhibits a dose-dependent inhibition of NAD+ formation with TED50 of 2 mg/kg in A2780 tumor xenograft models.
LSN3154567 also exhibits robust efficacy in multiple tumor models deficient in NAPRT1, does not cause observable retinal and hematological toxicities in the rodents when coadministered with nicotinic acid (NA).

物理化学性质&存储条件

分子量	419.496
分子式	C20H25N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-hydoxy-2-methyl-N-{2-[(pyridin-3-yloxy)acetyl]-1,2,3,4-tetrahydroisoquinolin-6-YL}propane-1-sulfonamide

参考文献

1. Zhao G, et al. Mol Cancer Ther. 2017 Dec;16(12):2677-2688.

LSN 3154567 (LSN-3154567;LSN3154567)

生物&药学活性

物理化学性质&存储条件

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LSN 3154567 (LSN-3154567;LSN3154567)

生物&药学活性

物理化学性质&存储条件

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