| Cat. No. |
Product Name |
Information |
| PC-26127 |
JNJ-3792165
GPR139 antagonist
|
JNJ-3792165 is a potent and selective antagonist at GPR139 with high affinity for human GPR139 (pKi =7.7, displacement of [3H] JNJ-6353054), behaves as an antagonist in [35S]GTPγS assay (pKb=7.4) and calcium mobilization assay. |
| PC-72146 |
TAK-041
GPR139 agonist
|
TAK-041 (Zelatriazin, NBI-1065846) is a potent, selective, brain-penetrant GPR139 agonist with EC50 of 22 nM (CHO-T-REx Ca2+ assays), Ki of 119 nM. |
| PC-36128 |
GPR139 agonist AC4
GPR139 agonist
|
GPR139 agonist AC4 is a novel small molecule GPR139 receptor agonist with EC50 of 220 nM in calcium mobilization assay in CHO-GPR139 cells. |
| PC-45741 |
JNJ-63533054
GPR139 agonist
|
JNJ-63533054 (JNJ63533054) is a potent, selective GPR139 agonist that specifically activates human GPR139 in the calcium mobilization with EC50 of 16 nM. |
| PC-26126 |
GPR139 agonist 20a
GPR139 agonist
|
GPR139 agonist 20a is a potent GPR139 agonist with EC50 of 24.7 nM, rescues the social interaction deficits and alleviates cognitive deficits in murine schizophrenia models. |
| PC-26125 |
TC-O 9311
GPR139 agonist
|
TC-O 9311 is a potent, selective agonist of orphan G protein-coupled receptor 139 (GPR139) with EC50 of 39 nM in calcium mobilization assay in CHO-K1 cells stably expressing human GPR139 receptor. |
| PC-26124 |
NCRW0005-F05
GPR139 antagonist
|
NCRW0005-F05 is a potent, synthetic antagonist for GPR139 with IC50 of 147.9 nM. |
| PC-26123 |
LP-360924
GPR139 agonist
|
LP-360924 is a potent, selective GPR139 agonist, stimulates cAMP production in cAMP assays. |
| PC-26122 |
LP-471756
GPR139 antagonist
|
LP-471756 is a potent, selective GPR139 antagonist with IC50 of 0.64 uM, inhibits LP-360924-stimulated cAMP production. |
