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首页-小分子抑制剂&激动剂-GPCR-GPR139-JNJ-63533054
JNJ-63533054

Chemical Structure : JNJ-63533054

CAS No.: 1802326-66-4

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JNJ-63533054 (JNJ63533054, JNJ 63533054)

货号: PC-45741Not For Human Use, Lab Use Only.

JNJ-63533054 (JNJ63533054) is a potent, selective GPR139 agonist that specifically activates human GPR139 in the calcium mobilization with EC50 of 16 nM.

规格 价格 库存 数量
5 mg ￥580 In stock
10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2480 In stock
100 mg ￥3980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JNJ-63533054 (JNJ63533054) is a potent, selective GPR139 agonist that specifically activates human GPR139 in the calcium mobilization with EC50 of 16 nM.
JNJ-63533054 shows similar potency for rat and mouse GPR139 receptor (rat EC50 =63 nM, mouse EC50=28 nM).
JNJ-63533054 decreases spontaneous locomotor activity in rats; shows no cross-reactivity in a panel of 50 known GPCRs, ion channels, and transporters, and displays suitable pharmacokinetic properties for in vivo studies.
JNJ-63533054 is CNS-penetrable and orally bioavailable.

物理化学性质&存储条件

分子量 316.7821
分子式 C17H17ClN2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzamide, 3-chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]-

参考文献

1. Liu C, et al. Mol Pharmacol. 2015 Nov;88(5):911-25.

2. Dvorak CA, et al. ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8.

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