| Cat. No. |
Product Name |
Information |
| PC-45650 |
SBI-0640756
eIF4F inhibitor
|
SBI-0640756 (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. |
| PC-42237 |
4E2RCat
eIF4E/eIF4G inhibitor
|
4E2RCat is a small molecule inhibitor of eIF4E-eIF4G interaction with IC50 of 13.5 uM in TR-FRET-based assay. |
| PC-45737 |
4EGI-1
eIF4E/eIF4G inhibitor
|
4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor with Kd of 25 uM (binding to eIF4E). |
| PC-26715 |
eIF2B inhibitor Compound B
eIF2B stabiliser, ISR activator
|
eIF2B inhibitor Compound B is a small molecule stabiliser and allosteric inhibitor of inactive state of eIF2B, shows stabilisation effect of the eIF2B:(P)eIF2-NTD interaction, stimulating the Integrated Stress Response (ISR). |
| PC-26714 |
eIF2B inhibitor Compound A-(S)
eIF2B stabiliser, ISR activator
|
eIF2B inhibitor Compound A-(S) is a small molecule stabiliser and allosteric inhibitor of inactive state of eIF2B, shows stabilisation effect of the eIF2B:(P)eIF2-NTD interaction with EC50 of 2.2 uM, stimulating the Integrated Stress Response (ISR). |
| PC-26561 |
Homoharringtonine
Translation elongation inhibitor
|
Homoharringtonine (HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation initiation elongation inhibitor. |
| PC-25457 |
4E1RCat
eIF4E-eIF4G inhibitor
|
4E1RCat is a small moleculeeIF4E:eIF4GI inhibitor, selectively inhibits cap-dependent translation initiation with IC50 of 4 uM, inhibits eIF4E:eIF4G and eIF4E:4E-BP1 interaction. |
| PC-25000 |
GCN2-IN-1
GCN2 inhibitor
|
GCN2-IN-1 (Compound A-92) is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with IC50 of <0.3 uM in enzyme assays and IC50 of 0.3-3 μM in cellular assays. |
| PC-24688 |
1Ai-4927
RPS10 inhibitor
|
1Ai-4927 is a specific inhibitor of ribosomal protein Rps10 with IC50 of 6.1 uM, targets the eIF1A-RPS10 complex,1Ai-4927 binds only RPS10, but not affect eIF1A. |
| PC-24545 |
HR-19011
eIF2α phosphorylation inducer
|
HR-19011 is a specific small molecule eIF2α phosphorylation inducer, increases the expression level of eIF2α downstream proteins, ATF and CHOP, shows antiproliferation in K562 cells with IC50 of 4.0 uM. |
| PC-24502 |
eIF4E-eIF4G inhibitor 4
eIF4E inhibitor
|
eIF4E-eIF4G inhibitor 4 is a specific small molecule inhibitor of eukaryotic initiation factor 4E (eIF4E) with Kd of 0.09 uM, disrupts the eIF4E:eIF4G interaction with EC50 of 1.4 uM (SW620 cell). |
| PC-23798 |
Salubrinal
eIF2α dephosphorylation inhibitor
|
Salubrinal is a selective inhibitor of eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha, eIF2α) dephosphorylation, also is a potential inhibitor of dual-specificity phosphatase 2 (Dusp2). |
