Salubrinal

Chemical Structure : Salubrinal

CAS No.: 405060-95-9

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货号: PC-23798Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥580	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
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生物&药学活性

Salubrinal is a selective inhibitor of eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha, eIF2α) dephosphorylation, also is a potential inhibitor of dual-specificity phosphatase 2 (Dusp2).
Salubrinal inhibits ER stress-mediated apoptosis induced by the protein glycosylation inhibitor tunicamycin (Tm) in a dose-dependent manner, with EC50 of 15 uM.
Salubrinal blocks eIF2alpha dephosphorylation mediated by a herpes simplex virus protein and inhibits viral replication. Salubrinal inhibits Dusp2 in LPS-activated macrophages as well as PMA/ionomycin-activated T lymphocytes and mast cells.
Salubrinal significantly suppressed the inflammatory signs of CAIA mice.

物理化学性质&存储条件

分子量	479.80
分子式	C21H17Cl3N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(2,2,2-Trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnamamide

参考文献

1. Boyce M, et al. Cell Death Differ. 2008 Mar;15(3):589-99.

2. Boyce M, et al. Science. 2005 Feb 11;307(5711):935-9.

3. Long K, et al. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3849-52.

4. Hamamura K, et al. Cell Signal. 2015 Apr;27(4):828-35.

Salubrinal

生物&药学活性

物理化学性质&存储条件

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Salubrinal

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