4EGI-1 | eIF4E/eIF4G inhibitor | Probechem Biochemicals

Chemical Structure : 4EGI-1

CAS No.: 315706-13-9

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4EGI-1 (eIF4E/eIF4G inhibitor)

货号: PC-45737Not For Human Use, Lab Use Only.

4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor with Kd of 25 uM (binding to eIF4E).

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3380	In stock
100 mg		Get quote

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生物&药学活性

4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor with Kd of 25 uM (binding to eIF4E).
4EGI-1 disrupts eIF4E/eIF4G association and inhibits cap-dependent translation.
4EGI-1 inhibits cellular expression of oncogenic proteins encoded by weak mRNAs, exhibits activity against multiple cancer cell lines.

物理化学性质&存储条件

分子量	451.2833
分子式	C18H12Cl2N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 35 mg/mL
Chemical Name/SMILES	Benzenepropanoic acid, α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-

参考文献

1. Moerke NJ, et al. Cell. 2007 Jan 26;128(2):257-67.

2. Wang W, et al. Oncotarget. 2016 Apr 19;7(16):21728-41.

3. Papadopoulos E, et al. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3187-95.

4EGI-1 (eIF4E/eIF4G inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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4EGI-1 (eIF4E/eIF4G inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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