| Cat. No. |
Product Name |
Information |
| PC-49534 |
NVS-PAK1-1
PAK1 inhibitor
|
NVS-PAK1-1 is a potent, selective and allosteric inhibitor of PAK1 with IC50 of 5 nM, potently inhibits PAK1 phosphorylation in vitro and in vivo. |
| PC-73199 |
FRAX486
PAK inhibitor
|
FRAX486 is potent, selective, brain-penetrant group I PAKs inhibitor with IC50 of 8.25, 39.5, and 55.3 nM for PAK1, PAK2 and PAK3, respectively. |
| PC-35567 |
CZh226
PAK4 inhibitor
|
CZh226 (CZh-226) is a potent, selective inhibitor of p21-activated kinase 4 (PAK4) with Ki of 9 nM, displays 346-fold selectivity over PAK-1. |
| PC-35566 |
CZh226 hydrochloride
PAK4 inhibitor
|
CZh226 hydrochloride (CZh-226) is a potent, selective inhibitor of p21-activated kinase 4 (PAK4) with Ki of 9 nM, displays 346-fold selectivity over PAK-1. |
| PC-43316 |
PF-3758309
PAK inhibitor
|
PF-3758309 (PF03758309) is a potent, ATP-competitive p21-activated kinase (PAK) inhibitor with Ki of 18.7 nM, shows similar enzymatic potency against other group B PAKs (PAK5 Ki=18.1 nM, PAK6 Ki=17.1 nM) and group A PAK1 (Ki=13.7 nM), less active against PAK2 and PAK3 (IC50=190 nM and 99 nM). |
| PC-43212 |
KPT-9274
NAMPT/PAK4 inhibitor
|
KPT-9274 (Padnarsertib) is a potent, specific, dual NAMPT and PAK4 inhibitor with IC50 of 120 nM (NAMPT), also is an orally bioavailable PAK4 allosteric modulator with IC50 of 30 nM in MS-751 cell MTT assay. |
| PC-63151 |
AZ13711265
PAK1 inhibitor
|
AZ13711265 is a potent, selective, in vivo active PAK1 inhibitor with IC50 of 0.58 nM, displays 880-, 2100- and 90-fold selectivity over Src, FGFR1, KDR and PAK4. |
| PC-63150 |
AZ13705339
PAK1 inhibitor
|
AZ13705339 is a potent, selective PAK1 inhibitor with IC50 of 0.33 nM, displays 14-, 470-, 4100- and 2600-fold selectivity over Src, FGFR1, KDR and PAK4. |
| PC-62724 |
KY-04045
PAK4 inhibitor
|
KY-04045 is a novel PAK4 inhibitor with IC50 of 8.7 uM, a basic building block in designing novel imidazo[4,5-b]pyridine-based PAK4 inhibitors.. |
| PC-62723 |
KY-04031
PAK4 inhibitor
|
KY-04031 is a PAK4 inhibitor with IC50 of 0.79 uM, a basic building block in designing novel imidazo[4,5-b]pyridine-based PAK4 inhibitors. |
| PC-62722 |
LCH7749944
PAK4 inhibitor
|
LCH7749944 (GNF-PF-2356) is a novel and potent PAK4 with IC50 of 14.93 uM, shows weak activity against other PAK family members. |
| PC-62721 |
GL-1196
PAK4 inhibitor
|
GL-1196 is a PAK4 inhibitor that effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclinD1 pathway and CDK4/6 expression. |
