AZ13711265 |CAS:2016806-55-4 Probechem Biochemicals

Chemical Structure : AZ13711265

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AZ13711265 (AZ 13711265)

货号: PC-63151Not For Human Use, Lab Use Only.

AZ13711265 is a potent, selective, in vivo active PAK1 inhibitor with IC50 of 0.58 nM, displays 880-, 2100- and 90-fold selectivity over Src, FGFR1, KDR and PAK4.

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生物&药学活性

AZ13711265 is a potent, selective, in vivo active PAK1 inhibitor with IC50 of 0.58 nM, displays 880-, 2100- and 90-fold selectivity over Src, FGFR1, KDR and PAK4.
AZ13711265 inhibits cellular pPAK1 inhibition in MCF10A cell line with IC50 of 110 nM.
AZ13711265 is an in vivo probe compound with oral exposure in mouse.

物理化学性质&存储条件

分子量	554.685
分子式	C28H35FN6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5-((2-((3-(ethylsulfonyl)-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)amino)-5-fluoropyrimidin-4-yl)(methyl)amino)-2,4-dimethylphenyl)methanol

参考文献

1. McCoull W, et al. ACS Med Chem Lett. 2016 Sep 14;7(12):1118-1123.

AZ13711265 (AZ 13711265)

生物&药学活性

物理化学性质&存储条件

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AZ13711265 (AZ 13711265)

生物&药学活性

物理化学性质&存储条件

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