CZh226 hydrochloride (CZh-226) | PAK4 inhibitor | Probechem Biochemicals

Chemical Structure : CZh226 hydrochloride

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CZh226 hydrochloride (CZh-226, CZh 226)

货号: PC-35566Not For Human Use, Lab Use Only.

CZh226 hydrochloride (CZh-226) is a potent, selective inhibitor of p21-activated kinase 4 (PAK4) with Ki of 9 nM, displays 346-fold selectivity over PAK-1.

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生物&药学活性

CZh226 hydrochloride (CZh-226) is a potent, selective inhibitor of p21-activated kinase 4 (PAK4) with Ki of 9 nM, displays 346-fold selectivity over PAK-1.
CZh226 also exhibits excellent kinase spectrum selectivity against a panel of 54 kinases (<80% inhibition at 0.1 uM).
CZh226 potently inhibits the migration and invasion of A549 tumor cells by regulating the PAK4-directed downstream signaling pathways in vitro.
CZh226 (CZh-226) is a valuable research probe for the further biological investigation of group II PAKs.

物理化学性质&存储条件

分子量	448.352
分子式	C20H23Cl2N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-(6-Chloro-4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)- quinazolin-2-yl)(3-methylpiperazin-1-yl)methanone hydrochloride

参考文献

1. Hao C, et al. J Med Chem. 2018 Jan 11;61(1):265-285.

CZh226 hydrochloride (CZh-226, CZh 226)

生物&药学活性

物理化学性质&存储条件

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CZh226 hydrochloride (CZh-226, CZh 226)

生物&药学活性

物理化学性质&存储条件

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