| Cat. No. |
Product Name |
Information |
| PC-24585 |
F368-0183
TRIP13 inhibitor
|
F368-0183 is a novel specific small molecule inhibitor of thyroid hormone receptor-interacting protein-13 (TRIP13) AAA+ ATPase, shows antiproliferative activity with IC50 of 5.25 μM (NCI-H929 cell line). |
| PC-24498 |
TRβ agonist IS25
TRβ agonist
|
TRβ agonist IS25 is a potent, selective agonist of thyroid hormone receptor-β (THRβ, TRβ) with EC50 of 458 nM, weakly activates TRα to 30% at 1 uM. |
| PC-24497 |
TRβ agonist TG68
TRβ agonist
|
TRβ agonist TG68 is a potent, selective agonist of thyroid hormone receptor-β (THRβ, TRβ), the prodrug of IS25 (TRβ, EC50=458 nM), promotes lipolysis through the activation of AMPK/ACC pathway. |
| PC-24487 |
Eprotirome
THRβ agonist
|
Eprotirome (KB-2115) is a liver-specific thyromimetic and thyroid hormone receptor-beta (TRβ) agonist with modestly higher affinity for TRβ than for TRα, reduces serum cholesterol independent of the LDL receptor. |
| PC-24184 |
Simedeutirom
THR-β agonist
|
Simedeutirom is a potent, selective thyroid hormone receptor agonist with EC50 of 0.1-1 uM. |
| PC-24128 |
ABX-002
THR-β agonist
|
Elunetirom (ABX-002, MA-JD21) is a potent, selective, CNS-permeable, thyromimetic thyroid hormone receptor beta (THR-β) agonist. |
| PC-22746 |
DCZ5418
TRIP13 inhibitor
|
DCZ5418 is a specific small molecule inhibitor of thyroid hormone receptor interacting protein 13 (TRIP13), shows anti-multiple myeloma activity in vitro and in vivo. |
| PC-22745 |
TRIP13 inhibitor TI17
TRIP13 inhibitor
|
TI17 is a specific small molecule inhibitor of thyroid hormone receptor interacting protein 13 (Trip13), effectively inhibits the proliferation and induces the cycle arrest and apoptosis of MM cells. |
