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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Thyroid Hormone Receptor (THR)-F368-0183
F368-0183

Chemical Structure : F368-0183

CAS No.: 1173769-15-7

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F368-0183

货号: PC-24585Not For Human Use, Lab Use Only.

F368-0183 is a novel specific small molecule inhibitor of thyroid hormone receptor-interacting protein-13 (TRIP13) AAA+ ATPase, shows antiproliferative activity with IC50 of 5.25 μM (NCI-H929 cell line).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

F368-0183 is a novel specific small molecule inhibitor of thyroid hormone receptor-interacting protein-13 (TRIP13) AAA+ ATPase, shows antiproliferative activity with IC50 of 5.25 μM (NCI-H929 cell line).
F368-0183 shows potent antiproliferative activity on both NCI-H929 and ARP-1 MM cell lines, with IC50 of 5.25 μM and 7.78 μM, respectively.

物理化学性质&存储条件

分子量 458.65
分子式 C29H38N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-(cyclohexyl(methyl)amino)propyl)-3-(1-phenyl-3-(p-tolyl)-1H-pyrazol-4-yl)propanamide

参考文献

1. Bunu SJ, RSC Med Chem. 2025 May 6. doi: 10.1039/d4md01008f.

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