THRβ agonist 14q

Chemical Structure : THRβ agonist 14q

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货号: PC-27284Not For Human Use, Lab Use Only.

THRβ agonist 14q is a potent, selective agonist of thyroid hormone receptor β (THRβ) with EC50 of 36 nM, with no discernible activity against THRα.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

THRβ agonist 14q is a potent, selective agonist of thyroid hormone receptor β (THRβ) with EC50 of 36 nM, with no discernible activity against THRα.
THRβ agonist 14q possesses excellent metabolic stability across species and favorable oral pharmacokinetics in mice.
THRβ agonist 14q significantly ameliorated hepatic steatosis, serum biomarkers, and liver gene expression profiles in murine MASH model, without observable cardiac toxicity.

物理化学性质&存储条件

分子量	438.61
分子式	C17H9Cl3F3NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,6-dichloro-5-((2-chloro-3-(trifluoromethyl)benzyl)oxy)-1H-indole-2-carboxylic acid

参考文献

1. Bo Wang, et al. J Med Chem. 2026 Jul 1. doi: 10.1021/acs.jmedchem.6c01478.