| Cat. No. |
Product Name |
Information |
| PC-28490 |
K-8794
ETB antagonist
|
K-8794 is a potent, selective and orally active selective endothelin-B-(ETB) receptor antagonist. |
| PC-28488 |
CIO-IAA
ETA/ETB receptor antagonist
|
CIO-IAA is a synthetic indole derivative and dual endothelin receptor ETA/ETB antagonist. |
| PC-23820 |
BQ-788
ETB receptor antagonist
|
BQ-788 (BQ788) is a potent, selective endothelin-B receptor (ETB) antagonist with IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, >1000-fold selective over ETA receptor. |
| PC-23409 |
Clazosentan
ETA antagonist
|
Clazosentan (Ro 61-1790) is a potent, selective endothelin A (ETA) receptor antagonist, 1000-fold selectivity for the ETA over ETB receptor on functional assays. |
| PC-22811 |
BQ3020
ETB receptor agonist
|
BQ3020 (BQ-3020) is a potent, selective endothelin receptor (ETB receptor) agonist, inhibits [125I] ET-1 binding to ETB receptor with IC50 of 0.2 nM. |
| PC-22810 |
BQ3020 ammonium
ETB receptor agonist
|
BQ3020 ammonium is a potent, selective endothelin receptor (ETB receptor) agonist, inhibits [125I] ET-1 binding to ETB receptor with IC50 of 0.2 nM. |
| PC-21324 |
Atrasentan
ETA inhibitor
|
Atrasentan (ABT-627, A-147627) is a potent, selective and orally active nonpeptide endothelin A-receptor (ETA) with IC50 of 0.055 nM. |
| PC-20918 |
Bosentan
ETA/ETB receptor antagonist
|
Bosentan (Ro 47-0203) is a potent, competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively. |
| PC-20103 |
IRL1620
ETB receptor agonist
|
IRL1620 (IRL-1620, Sovateltide, PMZ-1620) is a potent, selective agonist for endothelin ETB receptor with Ki of 0.016 nM, highly selective over ETA receptor (Ki=1900 nM). |
| PC-20050 |
ABT-546
ETA receptor inhibitor
|
ABT-546 (A-216546) is a potent, selective, small-molecule antagonist of ETA endothelin receptor with IC50 of 0.49 nM, shows high selectivity over ETB receptor. |
| PC-43394 |
Ambrisentan
ETA receptor inhibitor
|
Ambrisentan (BSF 208075, LU 208075) is a highly selective antagonist of the endothelin-1 type A receptor (ETA) for use in the treatment of pulmonary hypertension. |
| PC-43010 |
BQ-123
ETA receptor inhibitor
|
BQ-123 (PMZ 2123) is a potent, selective, non-competitive cyclic pentapeptide ETA receptor antagonist with IC50 of 7.3 nM. |
