BQ-123 (PMZ 2123) | ETA receptor inhibitor | Probechem Biochemicals

Chemical Structure : BQ-123

CAS No.: 136553-81-6

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BQ-123 (PMZ 2123, BQ123)

货号: PC-43010Not For Human Use, Lab Use Only.

BQ-123 (PMZ 2123) is a potent, selective, non-competitive cyclic pentapeptide ETA receptor antagonist with IC50 of 7.3 nM.

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5 mg	￥2180	In stock
10 mg	￥3580	In stock
25 mg	￥5480	In stock
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100 mg		Get quote

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生物&药学活性

BQ-123 (PMZ 2123) is a potent, selective, non-competitive cyclic pentapeptide ETA receptor antagonist with IC50 of 7.3 nM.
BQ-123 antagonizes endothelin-1-induced contractions in rabbit aorta, increases in inositol phosphates in cultured rat vascular smooth muscle A10 cells, shifts concentration-response curves in isolated rabbit aorta elicited by angiotensin II, but does not bind to angiotensin II receptors nor affect angiotensin II-induced increases in inositol phosphates.

物理化学性质&存储条件

分子量	610.7012
分子式	C31H42N6O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 34 mg/mL
Chemical Name/SMILES	Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)

参考文献

1. Ihara M, et al. J Cardiovasc Pharmacol. 1992;20 Suppl 12:S11-4.

2. Hiley CR, et al. Biochem Biophys Res Commun. 1992 Apr 15;184(1):504-10.

3. Ihara M, et al. Life Sci. 1992;50(4):247-55.

4. Webb ML, et al. Biochem Biophys Res Commun. 1992 Jun 30;185(3):887-92.

BQ-123 (PMZ 2123, BQ123)

生物&药学活性

物理化学性质&存储条件

参考文献

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BQ-123 (PMZ 2123, BQ123)

生物&药学活性

物理化学性质&存储条件

参考文献

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