| Cat. No. |
Product Name |
Information |
| PC-45421 |
GLPG0492
SARM
|
GLPG0492 (GLPG-0492) is an orally active, non-steroidal selective androgen receptor modulator (SARM) with in vitro potency of 13 nM. |
| PC-42652 |
RU 58841
AR inhibitor
|
RU 58841 (PSK-3841, HMR-3841) is a nonsteroidal, specific androgen receptor inhibitor, show potential for the topical treatment of androgen-dependent skin disorders such as acne, androgenetic alopecia and hirsutism. |
| PC-27015 |
KCI838PME
AR-ELK1 inhibitor
|
KCI838PME is a soluble 3’phosphate monoester prodrug of KCI838, AR-dependent growth by selectively binding to AR and blocking its association with ELK1, blocks AR binding to ELK1, inhibits enzalutamide-resistant patient-derived PCa tumor xenograft. |
| PC-27014 |
KCI838
AR-ELK1 inhibitor
|
KCI838 is a specific small molecule inhibitor of androgen receptor (AR)-dependent growth by selectively binding to AR and blocking its association with ELK1, blocks AR binding to ELK1. |
| PC-26992 |
AR-NTD antagonist K53
AR-NTD inhibitor
|
AR-NTD antagonist K53 is a potent, selective antagonist of androgen receptor N-terminal domain (AR-NTD) with SPR KD of 25.1 uM (AR-NTD-AF1 fragment), exhibits potent anti-proliferative activity in enzalutamide-resistant prostate cancer cells. |
| PC-26659 |
T878A-mutant AR inhibitor S-94
T878A-mutant AR antagonist
|
T878A-mutant AR inhibitor S-94 is a selective androgen receptor T878A-mutant androgen receptor (AR) antagonist, inhibits AR transcriptional activity (IC50=0.38 μM) and suppresses cell proliferation (IC50=10.32 μM) in LNCaP cells harboring the T878A-mutant AR. |
| PC-24994 |
ADGRD1 agonist GL64
GPR133 agonist
|
ADGRD1 agonist GL64 is a selective agonist of ADGRD1/GPR133 with EC50 of 3.98 uM in CRE-luciferase assays in ADGRD1-overexpressing HEK293T cells. |
| PC-23465 |
AR antagonist BG-15n
AR antagonist
|
AR antagonist BG-15n is a novel small molecule androgen receptor (AR) antagonist, binds to the ligand-binding domain of AR, promotes AR localization to the nucleus, yet potently and selectively down-regulates AR-target genes. |
| PC-23464 |
AR antagonist BG-15a
AR antagonist
|
AR antagonist BG-15a is a novel small molecule androgen receptor (AR) antagonist, binds to the ligand-binding domain of AR, promotes AR localization to the nucleus, yet potently and selectively down-regulates AR-target genes. |
| PC-21883 |
(+)-JJ-74-138
Androgen Receptor inhibitor
|
(+)-JJ-74-138 is a non-competitive androgen receptor (AR) antagonist, directly interacts with AR with SPR KD of 4.29 uM, inhibits AR with mutations in the LBD or lacking ligand binding domain (LBD). |
| PC-21502 |
AR inhibitor 1ae
AR inhibitor
|
AR inhibitor 1ae is a small-molecule inhibitor of the androgen receptor activation domain (AR AD) with IC50 of 1.54 uM in androgen-induced PSA-luciferase assays, inhibits AR-V7 transcriptional activity with IC50 of 4.1 uM. |
| PC-35497 |
Leelamine hydrochloride
|
Leelamine hydrochloride (Dehydroabietylamine) is a novel inhibitor of androgen receptor (AR), inhibits castration-resistant prostate cancer cells. |
