AR antagonist BG-15a

Chemical Structure : AR antagonist BG-15a

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货号: PC-23464Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

AR antagonist BG-15a is a novel small molecule androgen receptor (AR) antagonist, binds to the ligand-binding domain of AR, promotes AR localization to the nucleus, yet potently and selectively down-regulates AR-target genes.
BG-15a elicits a decrease in cell and tumor growth in vitro and in vivo in models of mCRPC.
BG-15a treatment causes the collapse of chromatin loops between enhancers and promoters at key genes in the AR-driven epigenome.

物理化学性质&存储条件

分子量	471.46
分子式	C21H16F3N7OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(3-(4-(1H-1,2,3-triazol-4-yl)benzyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-3-(trifluoromethyl)picolinonitrile

参考文献

1. Kohrt SE, et al. Proc Natl Acad Sci U S A. 2024 Nov 26;121(48):e2406239121.