diABZI-4 | STING agonist | Probechem Biochemicals

Chemical Structure : diABZI-4

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diABZI-4 (diABZI 4)

货号: PC-23117Not For Human Use, Lab Use Only.

diABZI-4 is a diamidobenzimidazole STING agonist, induces oligomerization of STING and activates STING and is highly effective in limiting SARS-CoV-2 replication.

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生物&药学活性

diABZI-4 is a diamidobenzimidazole STING agonist, induces oligomerization of STING and activates STING and is highly effective in limiting SARS-CoV-2 replication.
diABZI-4 has a more favorable solubility profile for in vivo studies in comparison to the previously reported diABZI-3 (Cat#PC-35785, STING agonist diABZI compound 3
).
diABZI-4 induces oligomerization of STING, transcription of IFNB1, CXCL10, TNF and IL6 and the secretion of IFN-β and TNF-α in primary human CD14+ monocytes.
diABZI-4 induces oligomerization of STING , phosphorylation of IRF3, TBK1, p65 and autophagy (LC3 conversion) in bone marrow derived macrophages (BMDMs), also induces the expression and secretion of IFN-β, CXCL10, TNF-α and IL-6.
diABZI-4 inhibits SARS-CoV-2 gene expression and replication in infected lung epithelial cells.
diABZI-4 (0.5mg/kg) protects against SARS-CoV-2 infection in hACE2 transgenic mice, promotes myeloid and lymphocyte activation in the lung.
diABZI-4 protects against SARS-CoV-2 infection through IFN-dependent and -independent mechanisms.

物理化学性质&存储条件

分子量	807.92
分子式	C40H49N13O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[(2E)-4-[5-(Aminocarbonyl)-7-[3-(dimethylamino)propoxy]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazole-5-carboxamide

参考文献

1. Humphries F, et al. Sci Immunol. 2021 May 18;6(59):eabi9002.

2. Broeckel R, et al. ACS Infect Dis. 2024 Sep 13;10(9):3392-3407.

diABZI-4 (diABZI 4)

生物&药学活性

物理化学性质&存储条件

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diABZI-4 (diABZI 4)

生物&药学活性

物理化学性质&存储条件

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