dWIZ-1 | WIZ degrader | Probechem Biochemicals

Chemical Structure : dWIZ-1

加入收藏

dWIZ-1 (WIZ degrader)

货号: PC-22585Not For Human Use, Lab Use Only.

dWIZ-1 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

dWIZ-1 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts.
dWIZ-1 increases CRBN-WIZ association with an EC50 of 547 nM.
dWIZ-1 induces HbF expression by direct binding to CRBN and subsequent recruitment and proteasomal degradation of WIZ through WIZ(ZF7).

物理化学性质&存储条件

分子量	399.49
分子式	C22H29N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-((R)-1-((R)-1-ethylpiperidin-2-yl)ethoxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

参考文献

1. PAMELA Y. TING, et al. SCIENCE, VOL. 385, NO. 670404 JUL 2024 : 91-99