dCK1α-2

Chemical Structure : dCK1α-2

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货号: PC-23543Not For Human Use, Lab Use Only.

dCK1α-2 is a potent, selective and orally bioavailable CK1α degrader with DC50 of 146 nM, Dmax of 84% in MOLM13 cells.

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生物&药学活性

dCK1α-2 is a potent, selective and orally bioavailable CK1α degrader with DC50 of 146 nM, Dmax of 84% in MOLM13 cells.
dCK1α-2 is capable of inducing ternary complex formation between CRBN and CK1α in HEK293T cells.
dCK1α-2 degraded CK1α in vitro and demonstrated significant selectivity in TMT proteomic studies in MOLM13 AML cells.
dCK1α-2 (5-20 mg/kg) effectively inhibits MOLM13 xenograft tumor growth on MOLM13 growth in mouse xenograft models.

物理化学性质&存储条件

分子量	494.94
分子式	C24H23ClN6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(5-(3-chloro-2-(morpholinomethyl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

参考文献

1. Lu Huang, et al. JACS Au. 2024 Nov 8;4(11):4423-4434.

dCK1α-2

生物&药学活性

物理化学性质&存储条件

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dCK1α-2

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