dCBP-30

Chemical Structure : dCBP-30

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货号: PC-27030Not For Human Use, Lab Use Only.

dCBP-30 is a potent, selective and orally active dual CBP/p300 degrader with DC50 at 4 h of 0.05 nM (CBP) and 0.04 nM (p300).

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生物&药学活性

dCBP-30 is a potent, selective and orally active dual CBP/p300 degrader with DC50 at 4 h of 0.05 nM (CBP) and 0.04 nM (p300).
dCBP-30 induces potent and selective cellular degradation of CBP and p300 in multiple myeloma cells.
dCBP-30 demonstrates potent viability inhibition across a panel of 25 MM cell lines with IC50 of <100 nM.
dCBP-30 is orally bioavailable and shows efficacy in tumor growth inhibition in MM tumor-bearing animals.

物理化学性质&存储条件

分子量	799.82
分子式	C39H40F3N11O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinoxalin-1(2H)-yl)-1-(1-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)-N-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide

参考文献

1. Tiwari PK, et al. Cell Rep. 2026 Jun 2;45(6):117464.

dCBP-30

生物&药学活性

物理化学性质&存储条件

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dCBP-30

生物&药学活性

物理化学性质&存储条件

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