dCBP-1 | p300/CBP PROTAC | Probechem Biochemicals

Chemical Structure : dCBP-1

CAS No.: 2484739-25-3

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dCBP-1 (p300/CBP PROTAC)

货号: PC-38019Not For Human Use, Lab Use Only.

dCBP-1 is a potent, selective chemical degrader of p300/CBP based on PROTAC.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5580	In stock
100 mg		Get quote

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生物&药学活性

dCBP-1 is a potent, selective chemical degrader of p300/CBP based on PROTAC.
dCBP-1 induces degradation of large proteins, including BCR-ABL and SMARCA2/4.
dCBP-1 also decreases IKZF1 and IKZF3 levels by direct degradation or transcription effects.
dCBP-1 induces near-complete p300/CBP degradation across other multiple myeloma cell lines.
dCBP-1 is a high-quality selective chemical inhibitor of p300/CBP function.

物理化学性质&存储条件

分子量	1028.13
分子式	C51H63F2N11O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5H-Pyrazolo[4,3-c]pyridine-5-carboxamide, 3-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1Hpyrazol-4-yl)-1(2H)-quinolinyl]-1-[1-[15-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]-1-oxo-4,7,10,13-tetraoxapentadec-1-yl]-4-piperidinyl]-1,4,6,7-tetrahydro-N-methyl-

参考文献

1. Vannam R, et al. Cell Chem Biol. 2021 Apr 15;28(4):503-514.e12.

dCBP-1 (p300/CBP PROTAC)

生物&药学活性

物理化学性质&存储条件

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dCBP-1 (p300/CBP PROTAC)

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物理化学性质&存储条件

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