ZSA-215 | STING agonist | Probechem Biochemicals

Chemical Structure : ZSA-215

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ZSA-215 (ZSA215)

货号: PC-24802Not For Human Use, Lab Use Only.

ZSA-215 is a potent oral STING agonist with EC50 of 3.3 uM, enhances STING signaling through promoting the phosphorylation of STING and interferon regulatory factor 3 (IRF3) and secretion of IFN-β.

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100 mg		Get quote

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生物&药学活性

ZSA-215 is a potent oral STING agonist with EC50 of 3.3 uM, enhances STING signaling through promoting the phosphorylation of STING and interferon regulatory factor 3 (IRF3) and secretion of IFN-β.
ZSA-215 displays potent activity for STINGR232 (EC50 = 9.0 μM) and mSTING (EC50 = 9.3 μM) in THP1 cells, also has significant STING WT binding affinity.
ZSA-215 does not induce interferon response in THP1 (STINGKO) cells.
ZSA-215 dramatically induces the expression of IFN-β, significantly increases the phosphorylation of STING and IRF3.
ZSA-215 (60 mg/kg, PO) dramatically suppressed tumor growth in MC38 tumor model.

物理化学性质&存储条件

分子量	402.28
分子式	C16H18FNO5Se
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-((3-Fluoro-5,6-dimethoxybenzo[b]selenophene-2-carboxamido)methyl)butanoic Acid

参考文献

1. Zhao HY, et al. J Med Chem. 2025 May 29. doi: 10.1021/acs.jmedchem.5c00296.

ZSA-215 (ZSA215)

生物&药学活性

物理化学性质&存储条件

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ZSA-215 (ZSA215)

生物&药学活性

物理化学性质&存储条件

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