ZNL-02-096 | Wee1 PROTAC | Probechem Biochemicals

Chemical Structure : ZNL-02-096

CAS No.: 2414418-49-6

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ZNL-02-096 (Wee1 PROTAC degrader)

货号: PC-22382Not For Human Use, Lab Use Only.

ZNL-02-096 is a potent, selective CRBN-dependent Wee1 kinase PROTAC degrader, induces potent and rapid Wee1 degradation, while sparing PLK1.

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2 mg	￥2580	In stock
5 mg	￥4580	In stock
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25 mg		Get quote
100 mg		Get quote

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生物&药学活性

ZNL-02-096 is a potent, selective CRBN-dependent Wee1 kinase PROTAC degrader, induces potent and rapid Wee1 degradation, while sparing PLK1.
ZNL-02-096 does not degrade IKZF1 or IKZF3.
ZNL-02-096 (100 nM) yielded CRBN-dependent effects on pCDK1 Y15, while high concentrations (1 μM or above) resulted in the combined effects of inhibition and degradation. ZNL-02-096 induces potent degradation of Wee1 in a CRBN- and proteasome-dependent manner, with maximal degradation achieved at 100 nM.
ZNL-02-096 induces DNA damage, apoptosis, and premature mitosis in MOLT4 cells.
ZNL-02-096 induces anti-proliferative effects and synergizes with Olaparib.

物理化学性质&存储条件

分子量	799.89
分子式	C42H45N11O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Isoindole-1,3(2H)-dione, 4-[[3-[4-[4-[[2,3-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-3-oxo-2-(2-propen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]-1-piperazinyl]propyl]amino]-2-(2,6-dioxo-3-piperidinyl)-

参考文献

1. Zhengnian Li, et al. Cell Chem Biol. 2020 Jan 16;27(1):57-65.e9.

ZNL-02-096 (Wee1 PROTAC degrader)

生物&药学活性

物理化学性质&存储条件

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ZNL-02-096 (Wee1 PROTAC degrader)

生物&药学活性

物理化学性质&存储条件

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