YX0597 | CDK9 PROTAC | Probechem Biochemicals

Chemical Structure : YX0597

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YX0597 (YX-0597)

货号: PC-24279Not For Human Use, Lab Use Only.

YX0597 is a potent, selective CDK9 PROTAC degrader, potently inhibits GEAC cell growth, especially in radiation-resistant tumor cells.

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生物&药学活性

YX0597 is a potent, selective CDK9 PROTAC degrader, potently inhibits GEAC cell growth, especially in radiation-resistant tumor cells.
YX0597 dose-dependently induced rapid and stable CDK9 degradation, in parallel with decreased RNA polymerase II S2 phosphorylation and expression of the CDK9 downstream effector MCl1 in GA0518 and AGS cells.
YX0597 potently inhibits tumor proliferation, metastasis, and targets cancer stem cells.
YX0597 epigenetically induces gene expression by increasing chromatin accessibility.
YX0597 dose-dependently decreased YAP1 and TEAD4, at the protein level.
VT00278, a YAP1/TEAD inhibitor, synergized with XY0597 treatment, significantly attenuating radiation-resistant tumor growth and progression, in vivo.

物理化学性质&存储条件

分子量	829.35
分子式	C42H49ClN8O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,3R)-N-(5-chloro-4-(5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl)-3-(7-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)heptanamido)cyclohexane-1-carboxamide

参考文献

1. Zhang YY, et al. bioRxiv [Preprint]. 2025 Feb 27:2025.02.22.639565.

YX0597 (YX-0597)

生物&药学活性

物理化学性质&存储条件

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YX0597 (YX-0597)

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物理化学性质&存储条件

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