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首页-抗体药物偶连体和PROTACs-PROTAC-YM281
YM281

Chemical Structure : YM281

CAS No.: 2230914-84-6

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YM281 (YM-281)

货号: PC-49078Not For Human Use, Lab Use Only.

YM281 is potent, EPZ6438-based, von Hippel-Lindau (VHL)-recruiting PROTAC degrader of EZH2, induces robust cell viability inhibition in DLBCL and other subtypes of lymphomas, displays promising antitumor activities in lymphoma xenografts and patient-derived primary lymphoma cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    YM281 is potent, EPZ6438-based, von Hippel-Lindau (VHL)-recruiting PROTAC degrader of EZH2, induces robust cell viability inhibition in DLBCL and other subtypes of lymphomas, displays promising antitumor activities in lymphoma xenografts and patient-derived primary lymphoma cells.

    物理化学性质&存储条件

    分子量 1018.284
    分子式 C56H71N7O9S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2S,4R)-1-((S)-2-(2-(3-((3'-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-5'-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4'-methyl-[1,1'-biphenyl]-4-yl)oxy)propoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

    参考文献

    1. Tu Y, et al. J Med Chem. 2021 Jul 22;64(14):10167-10184.

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