YKL-06-101

Chemical Structure : YKL-06-101

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货号: PC-73098Not For Human Use, Lab Use Only.

YKL-06-101 is a bivalent small molecule that combines mTOR inhibition (IC50=6 nM) and degradation of CDK8 (CDK8/Cyclin C IC50=31 nM).

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生物&药学活性

YKL-06-101 is a bivalent small molecule that combines mTOR inhibition (IC50=6 nM) and degradation of CDK8 (CDK8/Cyclin C IC50=31 nM).
The bivalent degrader YKL-06-101 stops proliferation of BCR-ABL1+ (Z119, BV173) and of BCR-ABL1− cells (REH) at concentrations below 1 uM.
YKL-06-101 reduces phosphorylation of S6S240/244, as indication of mTOR inhibition.
YKL-06-101 induces cell death in human leukemic cells.

物理化学性质&存储条件

分子量	1099.134
分子式	C58H57F3N8O11
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,6-dioxopiperidin-3-yl)-4-((18-(4-(4-(9-(isoquinolin-7-yl)-2-oxobenzo[h][1,6]naphthyridin-1(2H)-yl)-2-(trifluoromethyl)phenyl)piperazin-1-yl)-18-oxo-3,6,9,12,15-pentaoxaoctadecyl)amino)isoindoline-1,3-dione

参考文献

1. Ingeborg Menzl, et al. Nat Commun. 2019 Oct 18;10(1):4741.

YKL-06-101

生物&药学活性

物理化学性质&存储条件

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YKL-06-101

生物&药学活性

物理化学性质&存储条件

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