YAT2150 | Protein aggregation inhibitor | Probechem Biochemicals

Chemical Structure : YAT2150

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YAT2150 (YAT-2150)

货号: PC-23936Not For Human Use, Lab Use Only.

YAT2150 is a potent antileishmanial compound and inhibitor of protein aggregation, exhibits potent antiplasmodial activity with IC50 of 90 nM.

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生物&药学活性

YAT2150 is a potent antileishmanial compound and inhibitor of protein aggregation, exhibits potent antiplasmodial activity with IC50 of 90 nM.
YAT2150 also is strongly active against the chloroquine-resistant W2 strain (IC50 of 90 ± 1 nM) and several artemisinin-resistant strains, with IC50 values ranging from 90 to 160 nM.
YAT2150 arrested the life cycle of the pathogen at trophozoite stage.
YAT2150 is a powerful inhibitor of the aggregation of the model amyloid β peptide fragment 1-40.
YAT2150 reduces the amount of aggregated proteins in P. falciparum cultures, suggesting that the underlying antimalarial mechanism consists in a generalized impairment of proteostasis in the pathogen.

物理化学性质&存储条件

分子量	832.85
分子式	C46H64Br2N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	mono(1,1'-(decane-1,10-diyl)bis(4-((E)-4-(diethylamino)styryl)-3-methylpyridin-1-ium)) dibromide

参考文献

1. Román-Álamo L, et al. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0112723.

2. Bouzón-Arnáiz I, et al. BMC Biol. 2022 Oct 22;20(1):197.

YAT2150 (YAT-2150)

生物&药学活性

物理化学性质&存储条件

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YAT2150 (YAT-2150)

生物&药学活性

物理化学性质&存储条件

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