Y16 |CAS:429653-73-6 Probechem Biochemicals

Chemical Structure : Y16

CAS No.: 429653-73-6

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Y16 (RhoA-LARG inhibitor Y16)

货号: PC-43137Not For Human Use, Lab Use Only.

Y16 (RhoA-LARG inhibitor Y16) is a small-molecule inhibitor that specifically inhibits LARG binding to RhoA, binds to the junction site of the DH-PH domains of LARG with Kd of 80 nM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1880	In stock
50 mg	￥2980	In stock
100 mg	￥2980	In stock

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生物&药学活性

Y16 (RhoA-LARG inhibitor Y16) is a small-molecule inhibitor that specifically inhibits LARG binding to RhoA, binds to the junction site of the DH-PH domains of LARG with Kd of 80 nM.
Y16 does not affect RhoA interaction with DBL or LBC, also not interfere with the binding of Cdc42 and Rac1.
Y16 suppresses LARG catalyzed RhoA activation dose dependently, selectively inhibits serum-induced RhoA activity and RhoA-mediated signaling.
Y16 inhibits mammary sphere formation of MCF7 breast cancer cells but does not affect the nontransforming MCF10A cells, also works synergistically with Rhosin/G04;

物理化学性质&存储条件

分子量	384.4272
分子式	C24H20N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,5-Pyrazolidinedione, 4-[[3-[(3-methylphenyl)methoxy]phenyl]methylene]-1-phenyl-

参考文献

1. Shang X, et al. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3155-60.

2. Zhang XE, et al. PLoS One. 2016 May 17;11(5):e0155490.

3. Chen W, et al. Int J Biochem Cell Biol. 2017 Dec;93:12-24.

Y16 (RhoA-LARG inhibitor Y16)

生物&药学活性

物理化学性质&存储条件

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Y16 (RhoA-LARG inhibitor Y16)

生物&药学活性

物理化学性质&存储条件

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