XYD224 | BRD9 degrader | Probechem Biochemicals

Chemical Structure : XYD224

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XYD224 (XYD-224)

货号: PC-26928Not For Human Use, Lab Use Only.

XYD224 is a highly potent and selective BRD9 degrader with DC50 of 7.3 nM in MV4-11 cells, inhibits cell proliferation of a panel of AML cell lines with IC50 of 33 nM in MV4-11 cells.

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生物&药学活性

XYD224 is a highly potent and selective BRD9 degrader with DC50 of 7.3 nM in MV4-11 cells, inhibits cell proliferation of a panel of AML cell lines with IC50 of 33 nM in MV4-11 cells.
XYD224 efficiently induces BRD9 degradation in multiple AML cell lines, including MV4-11, MOLM-13, MOLM-16, Kasumi-1
XYD224 induces BRD9 degradation in a time-, dose-, CRBN-, and proteasome-dependent manner.
XYD224 (10 and 20 mg/kg (i.p.)) achieved tumor growth inhibition (TGI) rates of 70 and 79%, respectively, with a favorable safety profile in the MV4-11 xenograft model.

物理化学性质&存储条件

分子量	750.92
分子式	C43H51FN6O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((4-(7-((1-(4-(3-acetylindolizin-1-yl)-2,6-dimethoxybenzyl)piperidin-4-yl)methyl)-2,7-diazaspiro[3.5]nonan-2-yl)-3-fluorophenyl)amino)piperidine-2,6-dione

参考文献

1. Xin Tang, et al. J Med Chem. 2026 May 27. doi: 10.1021/acs.jmedchem.6c00491.

XYD224 (XYD-224)

生物&药学活性

物理化学性质&存储条件

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XYD224 (XYD-224)

生物&药学活性

物理化学性质&存储条件

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